Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 4/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558231 | 0.83 | NOTUM (0.46) | MLYCDKDM4E | |
| SCHEMBL1355684 | 0.83 | ACE2 (0.67) | ACE2BCL2MCL1GRM1MEN1 | |
| SCHEMBL7009458 | 0.80 | ACE2 (0.58) | ACE2BCL2MCL1GRM1MEN1 | |
| SCHEMBL5874054 | 0.77 | ACE2 (0.51) | ACE2GRM1MEN1CYP1A2KMT2A | |
| SCHEMBL8558758 | 0.76 | PLA2G2D (0.55) | PLA2G2DCES1HDAC1HDAC6MEN1 | |
| SCHEMBL13768197 | 0.76 | MLYCD (0.50) | CES1MLYCD | |
| SCHEMBL32665932 | 0.75 | CES1 (0.47) | PLA2G2DCES1MLYCDBCL2MCL1 | |
| SCHEMBL13129171 | 0.75 | CES1 (0.47) | PLA2G2DCES1MLYCDBCL2MCL1 | |
| SCHEMBL8506645 | 0.75 | ACE2 (0.50) | ACE2GRM1MEN1CYP1A2KMT2A | |
| SCHEMBL2159198 | 0.75 | ACE2 (0.54) | ACE2GRM1KDM4ERXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747541-A | Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0765868-A1 | Substituted bezoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |