SCHEMBL7009592

SCHEMBL7009592

C/C=C(\c1ccccc1)C(c1ccc(F)cc1)c1ccc(C=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYR P14679 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 1/20 0.39
PTGS2 P35354 1/20 0.39
PLA2G7 Q13093 1/20 0.38
LMNA P02545 1/20 0.38
ALPG P10696 1/20 0.38
HPGD P15428 1/20 0.38
ALDH1A1 P00352 2/20 0.37
CYP2A6 P11509 1/20 0.37
NFE2L2 Q16236 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7003804 0.83 KDM4E (0.50) SMN1; SMN2PLA2G7LMNAHPGDALDH1A1
SCHEMBL8768148 0.77 TDP1 (0.50) SMN1; SMN2PTGS2LMNAALDH1A1TDP1
SCHEMBL8593684 0.75 CES2 (0.59) SMN1; SMN2NPC1RAB9APLA2G7LMNA
Benzoic Acid SCHEMBL27844689 0.74 ALDH1A1 (0.67) SMN1; SMN2NPC1RAB9APLA2G7ALDH1A1
SCHEMBL7209286 0.73 KDM4E (0.55) TYRRAB9ALMNAHPGDALDH1A1
Benzaldehyde SCHEMBL28297125 0.73 ALDH1A1 (0.70) SMN1; SMN2NPC1RAB9AALDH1A1CYP2A6
SCHEMBL28349357 0.73 ALDH1A1 (0.53) SMN1; SMN2NPC1RAB9APTGS2PLA2G7
SCHEMBL11267446 0.73 TDP1 (0.42) RAB9ALMNAALDH1A1TDP1
Methyl Alcohol SCHEMBL28227404 0.71 CYP2A6 (0.52) TYRALDH1A1CYP2A6NFE2L2
SCHEMBL6905265 0.70 HDAC1 (0.58) LMNATDP1HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268389-A2 HALOGENATED TRIPHENYLETHYLENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS Bristol-Myers Squibb Pharma Company (US) 2003-01-02 EP disclosed
WO-2001077057-A2 HALOGENATED TRIPHENYLETHYLENE DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS DUPONT PHARMACEUTICALS COMPANY (US) 2001-10-18 WO disclosed