Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022793 | 0.85 | BRD4 (0.37) | BRD4CYP1A2HIF1AMMP2ANPEP | |
| SCHEMBL10749202 | 0.85 | FKBP1A (0.44) | BRD4CYP1A2HIF1AMMP2ANPEP | |
| SCHEMBL10818686 | 0.73 | BRD4 (0.39) | BRD4CYP1A2HIF1AFKBP1ASMN1; SMN2 | |
| SCHEMBL9685183 | 0.72 | ALDH1A1 (0.42) | HIF1AFKBP1AKMT2AALDH1A1MAPT | |
| SCHEMBL8394065 | 0.71 | FKBP1A (0.36) | BRD4CYP1A2HIF1AFKBP1AKMT2A | |
| SCHEMBL10366484 | 0.70 | ALDH1A1 (0.49) | KMT2AALDH1A1MAPT | |
| SCHEMBL16494534 | 0.69 | BRD4 (0.44) | BRD4CYP1A2HIF1AMMP2ANPEP | |
| SCHEMBL2597463 | 0.68 | BRD4 (0.45) | BRD4CYP1A2HIF1AMMP2ANPEP | |
| SCHEMBL2224192 | 0.67 | FKBP1A (0.50) | FKBP1ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL9686831 | 0.66 | ALDH1A1 (0.34) | KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307453-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010164-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-02-07 | — | — | WO | disclosed |