Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8171936 | 0.91 | PDE5A (0.48) | PDE5ACFTRPKMSMN1; SMN2MEN1 | |
| SCHEMBL8177394 | 0.91 | PRKCI (0.46) | CFTRPKMSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8185820 | 0.91 | HSD17B10 (0.49) | PDE5APKMSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL5123656 | 0.87 | PRKCI (0.58) | MEN1ALDH1A1LMNAKMT2AHSD17B10 | |
| SCHEMBL8177887 | 0.86 | PRKCI (0.46) | CFTRSMN1; SMN2ALDH1A1LMNACHRM4 | |
| SCHEMBL7013836 | 0.85 | PDE5A (0.52) | PDE5ACFTRPKMSMN1; SMN2MEN1 | |
| SCHEMBL7015745 | 0.84 | PTGS2 (0.53) | PDE5ASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL6216963 | 0.84 | ALDH1A1 (0.51) | PDE5APKMSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8180806 | 0.83 | FYN (0.46) | SMN1; SMN2MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL8184718 | 0.83 | FLT3 (0.51) | SMN1; SMN2MEN1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | claimed |
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | claimed |
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |