Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177394 | 0.95 | PRKCI (0.46) | PRKCIALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8171043 | 0.92 | PRKCI (0.44) | PRKCIALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8172557 | 0.92 | LMNA (0.41) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7622344 | 0.88 | PRKCI (0.61) | PRKCIALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8177717 | 0.86 | PRKCI (0.44) | PRKCIALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8170144 | 0.86 | CFTR (0.44) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL8183436 | 0.86 | LMNA (0.43) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7010123 | 0.86 | PDE5A (0.49) | PRKCIALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8180183 | 0.85 | ALDH1A1 (0.43) | ALDH1A1MAPTLMNAHTTTHRB | |
| SCHEMBL8182385 | 0.85 | PTGS2 (0.51) | PRKCIMAPTSMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |