Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011874 | 0.78 | SMN1; SMN2 (0.41) | TP53LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL7018141 | 0.77 | MAPK1 (0.40) | LMNASMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL7016967 | 0.72 | TP53 (0.58) | TP53LMNASMN1; SMN2THRBMAPT | |
| SCHEMBL21271713 | 0.70 | TP53 (0.67) | TP53LMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5712367 | 0.66 | ALDH1A1 (0.46) | LMNASMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL7010831 | 0.66 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL4074953 | 0.64 | PDE4A (0.56) | MAPTTDP1 | |
| SCHEMBL10332535 | 0.64 | MAPK1 (0.44) | LMNASMN1; SMN2MAPTALDH1A1HTT | |
| SCHEMBL10332278 | 0.64 | ALDH1A1 (0.46) | LMNASMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL7015456 | 0.63 | ALDH1A1 (0.38) | TP53LMNASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229910-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-10-01 | — | — | EP | claimed |
| EP-1044001-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-29 | — | — | EP | claimed |
| EP-1229910-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2002-08-14 | — | — | EP | claimed |
| EP-1100506-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-06-26 | — | — | EP | claimed |
| JP-2001524079-A | — | — | 2001-11-27 | — | — | JP | claimed |
| EP-1105389-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-10-17 | — | — | EP | claimed |
| EP-1105389-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-06-13 | — | — | EP | claimed |
| EP-1100506-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2001-05-23 | — | — | EP | claimed |
| WO-2001024797-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2001-04-12 | — | — | WO | claimed |
| EP-0946165-A4 | INTEGRIN ANTAGONISTS | MERCK & CO INC (US) | 2001-04-11 | — | — | EP | claimed |
| EP-0866705-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-03-03 | — | — | EP | claimed |
| EP-0880511-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-12-02 | — | — | EP | claimed |
| WO-1998046220-A1 | COMBINATION THERAPY FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | MERCK & CO., INC. (US) | 1998-10-22 | — | — | WO | claimed |
| WO-1998044797-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1998-10-15 | — | — | WO | claimed |
| EP-0866705-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-09-30 | — | — | EP | claimed |
| WO-1998018461-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | claimed |
| WO-1998018460-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | claimed |
| WO-1998008840-A1 | INTEGRIN ANTAGONISTS | MERCK & CO., INC. (US) | 1998-03-05 | — | — | WO | claimed |
| WO-1997026250-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-07-24 | — | — | WO | claimed |
| WO-1997014417-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-04-24 | — | — | WO | claimed |