Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | CTSS | P25774 | 4/20 | 0.39 |
| ▸ | REN | P00797 | 11/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CTSE | P14091 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5971691 | 0.89 | MAPK1 (0.36) | CTSKCTSSRENCTSDCTSE | |
| SCHEMBL5971129 | 0.89 | REN (0.41) | CTSKCTSSRENCTSLCTSB | |
| SCHEMBL5970799 | 0.80 | HTR6 (0.34) | — | |
| SCHEMBL7426317 | 0.78 | CTSK (0.37) | CTSKCTSSCTSLCTSB | |
| SCHEMBL7254317 | 0.77 | MAPK1 (0.35) | CTSKCTSSRENCTSLCTSB | |
| SCHEMBL4318514 | 0.77 | MAPK1 (0.36) | CTSKCTSSRENCTSLCTSB | |
| SCHEMBL7562353 | 0.77 | CYP3A4 (0.38) | CYP3A4 | |
| SCHEMBL6590370 | 0.77 | AAK1 (0.36) | AAK1 | |
| SCHEMBL6592602 | 0.76 | MAPK1 (0.34) | CTSKRENCTSLAAK1 | |
| SCHEMBL5971586 | 0.76 | REN (0.32) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278502-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-05-21 | — | — | EP | disclosed |
| EP-1278502-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001089451-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |