Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL238962 | 0.85 | L3MBTL1 (0.62) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL27439479 | 0.82 | L3MBTL1 (0.51) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL28219324 | 0.82 | L3MBTL1 (0.62) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL39472 | 0.81 | HPGD (0.78) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL6750951 | 0.81 | L3MBTL1 (0.57) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| 2,4'-Oxybis(Nitrobenzene) SCHEMBL9474586 | 0.81 | HSPB1 (0.62) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL1283885 | 0.81 | HSPB1 (0.67) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL7021137 | 0.79 | L3MBTL1 (0.56) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL641831 | 0.79 | HPGD (0.65) | L3MBTL1HPGDALDH1A1TDP1NPC1 | |
| SCHEMBL7123876 | 0.79 | L3MBTL1 (0.56) | L3MBTL1HPGDALDH1A1TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1134439-C | Pyrrolo [2,3D ] pyrimidines and their use as tyrosine kinase inhibitors | 艾博特股份有限两合公司 | 2004-01-14 | — | — | CN | claimed |
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | claimed |
| CN-1259950-A | Pyrrolo [2,3D] pyrimidines and their use as tyrosine kinase inhibitors | BASF AG (DE) | 2000-07-12 | — | — | CN | claimed |
| CN-1134439-C | Pyrrolo [2,3D ] pyrimidines and their use as tyrosine kinase inhibitors | 艾博特股份有限两合公司 | 2004-01-14 | — | — | CN | disclosed |
| CN-1259950-A | Pyrrolo [2,3D] pyrimidines and their use as tyrosine kinase inhibitors | BASF AG (DE) | 2000-07-12 | — | — | CN | disclosed |
| US-4578107-A | Herbicidal imidazolidine-2-one derivatives | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1986-03-25 | — | — | US | disclosed |