Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 14/20 | 0.54 |
| ▸ | PRKACA | P17612 | 4/20 | 0.54 |
| ▸ | PRKACG | P22612 | 4/20 | 0.54 |
| ▸ | PRKACB | P22694 | 4/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 3/20 | 0.45 |
| ▸ | CCND1 | P24385 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007889 | 0.92 | CAMK2D (0.62) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6983051 | 0.87 | CAMK2D (0.46) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL7009849 | 0.87 | CAMK2D (0.51) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL7008461 | 0.86 | CAMK2D (0.49) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6985276 | 0.86 | CAMK2D (0.49) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL7006503 | 0.85 | TPSAB1 (0.43) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| SCHEMBL7009039 | 0.83 | PRKACA (0.62) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6984540 | 0.83 | CAMK2D (0.46) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL7007891 | 0.83 | CAMK2D (0.49) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL6986094 | 0.81 | PRKACA (0.45) | CAMK2DPRKACAPRKACGPRKACBRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| US-6492409-B1 | SUCH AS 5-(1-(3-AMINOPROPYL)-3-INDOLYL)-1-(3-INDOLYL)-1,3-DIHYDROIMIDAZOL-2-ONE; PROTEIN KINASE C INHIBITORS; HIGH SOLUBILITY; REDUCED COLOR; TREATING INFLAMMATORY AND/OR IMMUNOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| US-6337342-B1 | ARYLIMIDAZOLONE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-01-08 | — | — | US | disclosed |