Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | S1PR4 | O95977 | 11/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16900169 | 0.84 | ALDH1A1 (0.62) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL18952487 | 0.81 | S1PR4 (0.62) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL13603899 | 0.81 | ALDH1A1 (0.60) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL187354 | 0.81 | NPC1 (0.64) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL11804530 | 0.80 | S1PR4 (0.44) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL8790468 | 0.79 | NPC1 (0.57) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL18952532 | 0.79 | NPC1 (0.58) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL3024027 | 0.78 | S1PR4 (0.64) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 | |
| SCHEMBL5143899 | 0.75 | NPC1 (0.63) | NPC1RAB9AS1PR4MAPTALDH1A1 | |
| SCHEMBL8326193 | 0.73 | ALDH1A1 (0.42) | NPC1RAB9AS1PR4MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582675-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | Itek Ventures Pty Ltd (AU) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011161446-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | THE UNIVERSITY OF NOTTINGHAM (GB) | 2011-12-29 | — | — | WO | disclosed |
| EP-1301487-A2 | VIRAL POLYMERASE INHIBITORS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004425-A2 | VIRAL POLYMERASE INHIBITORS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2002-01-17 | — | — | WO | disclosed |