Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 15/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3014193 | 0.83 | S1PR4 (0.45) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3018672 | 0.83 | S1PR4 (0.47) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL16900169 | 0.78 | ALDH1A1 (0.62) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7011056 | 0.78 | NPC1 (0.67) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3016577 | 0.75 | LMNA (0.43) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL18952487 | 0.73 | S1PR4 (0.62) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL13603899 | 0.73 | ALDH1A1 (0.60) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL187354 | 0.73 | NPC1 (0.64) | S1PR4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL22117070 | 0.71 | RAB9A (0.73) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL8790468 | 0.71 | NPC1 (0.57) | S1PR4NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204245-A1 | Amino-pyridines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100204245-A1 | Amino-pyridines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-08-12 | — | — | US | disclosed |
| US-20100204245-A1 | Amino-pyridines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-08-12 | — | — | US | disclosed |
| US-7732457-B2 | Amino-pyridines as inhibitors of β-secretase | WYETH LLC (US) | 2010-06-08 | — | — | US | disclosed |
| US-7732457-B2 | Amino-pyridines as inhibitors of β-secretase | WYETH LLC (US) | 2010-06-08 | — | — | US | disclosed |
| US-7732457-B2 | Amino-pyridines as inhibitors of β-secretase | WYETH LLC (US) | 2010-06-08 | — | — | US | disclosed |
| EP-1844035-A1 | AMINO-PYRIDINES AS INHIBITORS OF BETA-SECRETASE | Wyeth (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006083760-A1 | AMINO-PYRIDINES AS INHIBITORS OF β-SECRETASE | WYETH (US) | 2006-08-10 | — | — | WO | disclosed |
| WO-2006083760-A1 | AMINO-PYRIDINES AS INHIBITORS OF β-SECRETASE | WYETH (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173049-A1 | enzyme inhibitors such as 6-{2-(2-Chloro-phenyl)-5-[4-(pyrimidin-2-yloxy)-phenyl]pyrrol-1-ylmethyl}-pyridin-2-ylamine, used to treat beta-amyloid deposits and neurofibrillary tangles; Alzheimer's disease | WYETH (US) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204245-A1 | Amino-pyridines As Inhibitors Of Beta-secretase | BACE1, BACE2, APP | S1PR4 4264/4885NPC1 493/4885RAB9A 2339/4885 |
| US-20060173049-A1 | enzyme inhibitors such as 6-{2-(2-Chloro-phenyl)-5-[4-(pyrimidin-2-yloxy)-phenyl]pyrrol-1-ylmethyl}-pyridin-2-ylamine, used to treat beta-amyloid deposits and neurofibrillary tangles; Alzheimer's disease | BACE1, BACE2, PSEN1 | S1PR4 3091/4885NPC1 365/4885RAB9A 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.