Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3301954 | 0.74 | ALDH1A1 (0.62) | NFE2L2HPGDALDH1A1CYP1A1CYP1A2 | |
| SCHEMBL6935115 | 0.74 | ALDH1A1 (0.45) | NFE2L2MAPTNPC1HTTALDH1A1 | |
| SCHEMBL2089900 | 0.72 | NFE2L2 (0.47) | NFE2L2MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27686167 | 0.70 | TDP1 (0.54) | MAPTRAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL11410638 | 0.69 | MAPT (0.46) | NFE2L2MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11406154 | 0.69 | MAPT (0.56) | NFE2L2MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11410654 | 0.69 | MAPT (0.46) | NFE2L2MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL600882 | 0.68 | — | — | |
| SCHEMBL11410428 | 0.68 | MAPT (0.57) | NFE2L2MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL867378 | 0.67 | PTGS2 (0.41) | NFE2L2HTR2AHTR2CKCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268450-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001092235-A1 | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-12-06 | — | — | WO | disclosed |