Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.31 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.31 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012111 | 0.79 | NPSR1 (0.38) | NPSR1MAT2AGABRA1GABRA5GABRA3 | |
| SCHEMBL7013042 | 0.72 | NPSR1 (0.42) | NPSR1TLR7CYP1A2KMT2AMEN1 | |
| SCHEMBL1146283 | 0.69 | MAT2A (0.34) | MAT2ATLR7CYP1A2KMT2AMEN1 | |
| SCHEMBL7012885 | 0.67 | NPSR1 (0.41) | NPSR1TLR7KMT2AMEN1ALDH1A1 | |
| SCHEMBL7010160 | 0.66 | KDM4E (0.39) | NPSR1CYP1A2KMT2AMEN1NPC1 | |
| SCHEMBL7010158 | 0.66 | KDM4E (0.39) | NPSR1CYP1A2KMT2AMEN1NPC1 | |
| SCHEMBL5271758 | 0.66 | KDM4E (0.44) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL5271761 | 0.61 | RIPK1 (0.60) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL6621602 | 0.61 | NPSR1 (0.40) | NPSR1POLBMAPTTSHRMAPK1 | |
| SCHEMBL19312647 | 0.61 | ADORA1 (0.58) | CYP1A2KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |