Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | MGMT | P16455 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013042 | 0.81 | NPSR1 (0.42) | NPSR1HTTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL19539399 | 0.78 | POLB (0.38) | NPSR1MAPTHTTSMN1; SMN2TDP1 | |
| SCHEMBL7014795 | 0.77 | NPSR1 (0.46) | NPSR1MAPTHTTSMN1; SMN2TDP1 | |
| SCHEMBL27631417 | 0.74 | ADORA3 (0.45) | NPSR1MAPTHTTALDH1A1RECQL | |
| SCHEMBL166734 | 0.72 | ALDH1A1 (0.41) | NPSR1MAPTHTTGAAALDH1A1 | |
| SCHEMBL21047996 | 0.71 | POLB (0.38) | NPSR1MAPTTDP1ALDH1A1RECQL | |
| SCHEMBL27631927 | 0.69 | LMNA (0.44) | NPSR1MAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16182532 | 0.69 | MAPT (0.41) | MAPTHTTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7012111 | 0.68 | NPSR1 (0.38) | NPSR1MAPTALDH1A1POLBLMNA | |
| SCHEMBL2458774 | 0.68 | TLR7 (0.36) | MAPTSMN1; SMN2TDP1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |