Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 12/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 12/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013315 | 0.94 | TOP2A (0.61) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7006571 | 0.92 | TOP2A (0.51) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL7007624 | 0.91 | TOP2A (0.49) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL8322686 | 0.91 | TOP2A (0.41) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL7014091 | 0.91 | TOP2A (0.41) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL7008688 | 0.90 | ADRB2 (0.45) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL7014704 | 0.89 | TOP2A (0.49) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL7008331 | 0.89 | TOP2A (0.47) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL7008348 | 0.86 | ALDH1A1 (0.47) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7502981 | 0.86 | HDAC1 (0.41) | TOP2ATOP2BKCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |