Sugi Predict

Sugi Predict / Compounds / SCHEMBL701221

SCHEMBL701221

SCHEMBL701221

Cc1c(Br)ccc(S(C)(=O)=O)c1C=NO

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.35
▸ GFER P55789 1/20 0.35
▸ HTT P42858 5/20 0.34
▸ LMNA P02545 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ MAPT P10636 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ MAPK1 P28482 2/20 0.32
▸ TSHR P16473 1/20 0.32
▸ ACHE P22303 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.30
▸ PIK3CD O00329 1/20 0.30
▸ PIK3CA P42336 1/20 0.30
▸ PIK3CB P42338 1/20 0.30
▸ PIK3CG P48736 1/20 0.30
▸ EPAS1 Q99814 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL701220 1.00 HPGD (0.35) HPGDGFERHTTLMNAMEN1
SCHEMBL7234146 1.00 HPGD (0.35) HPGDGFERHTTLMNAMEN1
SCHEMBL699707 0.80 HPGD (0.35) HPGDGFERHTTLMNAMEN1
SCHEMBL699706 0.80 HPGD (0.35) HPGDGFERHTTLMNAMEN1
SCHEMBL6665599 0.80 HTT (0.39) HPGDGFERHTTLMNAMEN1
SCHEMBL6665602 0.80 HTT (0.39) HPGDGFERHTTLMNAMEN1
SCHEMBL700676 0.79 L3MBTL1 (0.40) ALDH1A1L3MBTL1PIK3CDPIK3CAPIK3CB
SCHEMBL5836252 0.77 L3MBTL1 (0.35) ALDH1A1L3MBTL1
SCHEMBL4700348 0.74 VCAM1 (0.38) HPGDHTTLMNAMEN1KMT2A
SCHEMBL4700345 0.74 VCAM1 (0.38) HPGDHTTLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118788251-B Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2025-02-07 — — CN claimed
CN-119350263-A Preparation method of 3- (3-bromo-2-methyl-6-methylsulfonylphenyl) -4, 5-dihydroisoxazole 江西天宇化工有限公司 2025-01-24 — — CN claimed
CN-118788251-A Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2024-10-18 — — CN claimed
CN-121248452-A Preparation method of 3-bromo-2-methyl-6-methylsulfonyl benzaldehyde oxime 山东京博农化科技股份有限公司 2026-01-02 — — CN disclosed
CN-121248452-A Preparation method of 3-bromo-2-methyl-6-methylsulfonyl benzaldehyde oxime 山东京博农化科技股份有限公司 2026-01-02 — — CN disclosed
CN-118788251-B Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2025-02-07 — — CN disclosed
CN-118788251-B Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2025-02-07 — — CN disclosed
CN-119350263-A Preparation method of 3- (3-bromo-2-methyl-6-methylsulfonylphenyl) -4, 5-dihydroisoxazole 江西天宇化工有限公司 2025-01-24 — — CN disclosed
CN-119350263-A Preparation method of 3- (3-bromo-2-methyl-6-methylsulfonylphenyl) -4, 5-dihydroisoxazole 江西天宇化工有限公司 2025-01-24 — — CN disclosed
CN-118788251-A Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2024-10-18 — — CN disclosed
CN-118788251-A Method for preparing 3- [ 3-bromo-2-methyl-6- (methylsulfonyl) phenyl ] -4, 5-dihydroisoxazole 苏州开元民生科技股份有限公司 2024-10-18 — — CN disclosed
US-6608209-B2 Reacting a nitro-o-methylphenyl compound with an organic nitrite in presence of a base to give an oxime, cyclizing the oxime with an alkene in presence of a base to give an intermediate, reducing nitrogroup in presence of catalyst BASF AKTIENGESELLSCHAFT (DE) 2003-08-19 — — US disclosed
US-6525204-B1 Oximination reaction of nitro-o-methylphenyl compound with organic nitrite; cyclization with alkene in basic catalyst presence; reduction, bromination, oxidation, carboxylation BASF AKTIENGESELLSCHAFT (DE) 2003-02-25 — — US disclosed
US-20030028033-A1 Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes DEYN WOLFGANG VON (DE) 2003-02-06 — — US disclosed
US-20030018200-A1 Preparation of isoxazolin-3-ylacylbenzenes BASF SE (DE) 2003-01-23 — — US disclosed
US-6469176-B1 CROP PROTECTION COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 2002-10-22 — — US disclosed
EP-1129082-A1 METHOD AND NOVEL INTERMEDIATE PRODUCTS FOR PRODUCING ISOXAZOLIN-3-YL-ACYLBENZENES BASF AKTIENGESELLSCHAFT (DE) 2001-09-05 — — EP disclosed
EP-1077955-A1 METHOD FOR PRODUCING ISOXAZOLINE-3-YL-ACYL BENZENE BASF AKTIENGESELLSCHAFT (DE) 2001-02-28 — — EP disclosed
WO-2000029394-A1 METHOD AND NOVEL INTERMEDIATE PRODUCTS FOR PRODUCING ISOXAZOLIN-3-YL-ACYLBENZENES BASF AKTIENGESELLSCHAFT (DE) 2000-05-25 — — WO disclosed
WO-1999058509-A1 METHOD FOR PRODUCING ISOXAZOLINE-3-YL-ACYL BENZENE BASF AKTIENGESELLSCHAFT (DE) 1999-11-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030018200-A1 Preparation of isoxazolin-3-ylacylbenzenes CYP2F1, UQCRB, CYP1B1 HPGD 2407/4885GFER 746/4885HTT 3649/4885
US-20030028033-A1 Process and novel intermediates for preparing isoxazolin-3-ylacyl benzenes CYP2F1, CBR3, CBR1 HPGD 1448/4885GFER 911/4885HTT 3867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.