Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022295 | 0.82 | KDM4E (0.56) | EGLN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL7017409 | 0.82 | EGLN1 (0.53) | EGLN1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL7020816 | 0.78 | HSP90AA1 (0.63) | EGLN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL1654659 | 0.76 | CYP3A4 (0.54) | EGLN1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL7021606 | 0.74 | EPHX1 (0.52) | LMNAKMT2ACYP3A4ALDH1A1MAPT | |
| SCHEMBL7015297 | 0.74 | NPC1 (0.49) | NPC1RAB9AKDM4EMEN1LMNA | |
| SCHEMBL7016726 | 0.73 | SMN1; SMN2 (0.52) | NPC1RAB9AKDM4EMEN1LMNA | |
| SCHEMBL6435155 | 0.73 | LMNA (0.49) | EGLN1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL5696271 | 0.72 | NPC1 (0.59) | NPC1RAB9AALDH1A1MAPTCA12 | |
| SCHEMBL7011986 | 0.71 | HSP90AA1 (0.51) | EGLN1NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155017-B1 | [1,8] NAPHTHYRIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | SHIRE BIOCHEM INC (CA) | 2003-01-15 | — | — | EP | claimed |