Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | PNMT | P11086 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574317 | 0.86 | IDO1 (0.43) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL17231912 | 0.86 | CYP2A6 (0.43) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL21741544 | 0.86 | CYP2A6 (0.43) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL14625313 | 0.86 | CYP2A6 (0.43) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL1307331 | 0.86 | IDO1 (0.43) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL9479134 | 0.85 | CYP3A4 (0.45) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL7424709 | 0.83 | IDO1 (0.41) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL42557 | 0.82 | PNMT (0.52) | CYP2A6IDO1CYP3A4PNMTALOX15 | |
| SCHEMBL109291 | 0.82 | IDO1 (0.60) | CYP2A6IDO1CYP3A4PNMTSMN1; SMN2 | |
| SCHEMBL7378131 | 0.81 | CYP2A6 (0.40) | CYP2A6IDO1CYP3A4PNMTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655399-B1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2017-09-27 | — | — | EP | disclosed |
| EP-2655399-B1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2017-09-27 | — | — | EP | disclosed |
| EP-2655399-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | The Medicines Company (Leipzig) GmbH (DE) | 2013-10-30 | — | — | EP | disclosed |
| US-8497245-B2 | Trypsin-like serine protease inhibitors, their preparation and use as selective inhibitors of the clotting factors IIa and Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-07-30 | — | — | US | disclosed |
| EP-1926743-B1 | 2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa | MEDICINES CO LEIPZIG GMBH (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-1926743-B1 | 2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa | MEDICINES CO LEIPZIG GMBH (DE) | 2013-05-15 | — | — | EP | disclosed |
| US-20120252743-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| WO-2012083436-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012083436-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |
| US-8124587-B2 | 2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-8124587-B2 | 2-(aminomethyl)-5-chlorobenzylamide derivatives and their use as inhibitors of the clotting factor Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-02-28 | — | — | US | disclosed |
| US-20090117185-A1 | 2-(Aminomethyl)-5-Chlorobenzylamide Derivatives and their use as Inhibitors of the Clotting Factor Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| US-20090117185-A1 | 2-(Aminomethyl)-5-Chlorobenzylamide Derivatives and their use as Inhibitors of the Clotting Factor Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| US-20090117185-A1 | 2-(Aminomethyl)-5-Chlorobenzylamide Derivatives and their use as Inhibitors of the Clotting Factor Xa | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| EP-1926743-A1 | 2-(AMINOMETHYL)-5-CHLOROBENZYLAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CLOTTING FACTOR Xa | Curacyte Chemistry GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| EP-1926743-A1 | 2-(AMINOMETHYL)-5-CHLOROBENZYLAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CLOTTING FACTOR Xa | Curacyte Chemistry GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007031343-A1 | 2-(AMINOMETHYL)-5-CHLOROBENZYLAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CLOTTING FACTOR Xa | CURACYTE CHEMISTRY GMBH (DE) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007031343-A1 | 2-(AMINOMETHYL)-5-CHLOROBENZYLAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE CLOTTING FACTOR Xa | CURACYTE CHEMISTRY GMBH (DE) | 2007-03-22 | — | — | WO | disclosed |
| CN-1894214-A | New 5,6-dihydropyrin-2-one compounds useful as inhibitors of thrombin | ASTRAZENECA AB (SE) | 2007-01-10 | — | — | CN | disclosed |
| US-5198564-A | Anticarcinogenic agents | BEIJING POLYTECHNIC UNIVERSITY (CN) | 1993-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252743-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | F2, F12, SERPINC1 | CYP2A6 964/4885IDO1 1741/4885CYP3A4 746/4885 |
| US-20090117185-A1 | 2-(Aminomethyl)-5-Chlorobenzylamide Derivatives and their use as Inhibitors of the Clotting Factor Xa | F2, F11, TFPI | CYP2A6 515/4885IDO1 1291/4885CYP3A4 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.