Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501712 | 0.88 | PREP (0.48) | PREPNPC1ALDH1A1HPGDTSHR | |
| SCHEMBL9501764 | 0.87 | ACE (0.55) | NPC1ALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL8696411 | 0.80 | POLB (0.73) | NPC1ALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL9500411 | 0.76 | ALDH1A1 (0.50) | NPC1ALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL5742878 | 0.75 | CACNA1A (0.62) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5742876 | 0.75 | CACNA1A (0.62) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6285958 | 0.74 | PREP (0.65) | PREPNPC1RAB9A | |
| SCHEMBL6285952 | 0.74 | PREP (0.65) | PREPNPC1RAB9A | |
| SCHEMBL9501243 | 0.74 | KLK5 (0.49) | NPC1ALDH1A1HPGDTSHRRAB9A | |
| SCHEMBL28218046 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861246-B1 | PROLYL ENDOPEPTIDASE INHIBITORS, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | SANDOR ERDOE DR (HU) | 2003-10-15 | — | — | EP | disclosed |
| US-6191161-B1 | NERVOUS SYSTEM DISORDERS | CHINOIN GYOGYSZER ES VEGYESZETI (HU) | 2001-02-20 | — | — | US | disclosed |
| EP-0861246-A1 | PROLYLENDOPEPTIDASE INHIBITORS | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1998-09-02 | — | — | EP | disclosed |
| WO-1998035960-A1 | PROLYLENDOPEPTIDASE INHIBITORS | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) | 1998-08-20 | — | — | WO | disclosed |
| WO-1997007116-A1 | PROLYLENDOPEPTIDASE INHIBITORS | CHINOIN GYÓGYSZER ÉS VEGYÉSZETI (HU) | 1997-02-27 | — | — | WO | disclosed |
| EP-0232849-B1 | PYRROLIDINEAMIDE DERIVATIVE OF ACYLAMINO ACID, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5198458-A | Pyrrolidineamide derivatives of acylamino acid and pharmaceutical composition containing the same | SUNTORY LIMITED (JP) | 1993-03-30 | — | — | US | disclosed |
| US-4826870-A | CURING AMNESIA | SUNTORY LIMITED (JP) | 1989-05-02 | — | — | US | disclosed |