Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500411 | 0.91 | ALDH1A1 (0.50) | ACEALDH1A1TSHRNPC1HPGD | |
| SCHEMBL9501712 | 0.87 | PREP (0.48) | ALDH1A1TSHRNPC1HPGDRAB9A | |
| SCHEMBL9501238 | 0.78 | FKBP1A (0.54) | KLK5GAAFKBP1AACENPC1 | |
| SCHEMBL9501764 | 0.78 | ACE (0.55) | ACEALDH1A1TSHRNPC1HPGD | |
| SCHEMBL7013528 | 0.74 | PREP (0.57) | ALDH1A1TSHRNPC1HPGDRAB9A | |
| SCHEMBL10756387 | 0.74 | LTA4H (0.56) | KLK5ACEALDH1A1NPC1HPGD | |
| SCHEMBL11141447 | 0.73 | PTGS1 (0.65) | SMN1; SMN2PTGS1MEN1KMT2A | |
| SCHEMBL26213384 | 0.73 | POLB (0.50) | KLK5FKBP1AACEALDH1A1RAB9A | |
| SCHEMBL13885358 | 0.73 | POLB (0.50) | KLK5FKBP1AACEALDH1A1RAB9A | |
| SCHEMBL6639156 | 0.73 | ACE (0.59) | KLK5FKBP1AACEALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232849-B1 | PYRROLIDINEAMIDE DERIVATIVE OF ACYLAMINO ACID, PHARMACEUTICAL COMPOSITION AND USE | SUNTORY LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-4826870-A | CURING AMNESIA | SUNTORY LIMITED (JP) | 1989-05-02 | — | — | US | disclosed |
| EP-0232849-A2 | Pyrrolidineamide derivative of acylamino acid, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1987-08-19 | — | — | EP | disclosed |