Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 13/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.56 |
| ▸ | RORA | P35398 | 4/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.56 |
| ▸ | RORB | Q92753 | 4/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.56 |
| ▸ | MLYCD | O95822 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2938741 | 0.79 | RORC (0.77) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL2940867 | 0.78 | RORC (0.49) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL7016049 | 0.75 | RORC (0.76) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL7013542 | 0.73 | RORC (0.76) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL16731518 | 0.71 | RORC (0.81) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL2938172 | 0.70 | MLYCD (1.00) | MLYCD | |
| SCHEMBL13239428 | 0.69 | ALDH1A1 (0.57) | RORCRORANR1H3ALDH1A1HSD11B1 | |
| SCHEMBL14732108 | 0.69 | RORC (0.79) | RORCNR1I2RORANR1H2RORB | |
| SCHEMBL12334077 | 0.68 | RORC (0.81) | RORCNR1I2RORANR1H2RORB | |
| T091317 SCHEMBL457231 | 0.67 | RORC (1.00) | RORCNR1I2RORANR1H2RORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4503232-B2 | — | — | 2010-07-14 | — | — | JP | claimed |
| JP-2004521113-A | — | — | 2004-07-15 | — | — | JP | claimed |
| US-20040087627-A1 | Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-05-06 | — | — | US | claimed |
| EP-1353662-A2 | METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-10-22 | — | — | EP | claimed |
| WO-2002058690-A2 | METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-08-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087627-A1 | Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors | ME2, PC, ACACA | RORC 2163/4885NR1I2 2876/4885RORA 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.