Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013419 | 0.81 | GSK3B (0.42) | TMEM97SIGMAR1GSK3BDRD2DRD1 | |
| SCHEMBL27986060 | 0.80 | TMEM97 (0.40) | TMEM97SIGMAR1KMT2AMEN1GSK3B | |
| SCHEMBL28750703 | 0.80 | ALDH1A1 (0.37) | SLC18A3MAPK1KMT2ALMNAHTT | |
| SCHEMBL8584281 | 0.80 | ADRA2A (0.48) | SLC18A3LMNAALDH1A1 | |
| SCHEMBL3272922 | 0.79 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3272931 | 0.79 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3277741 | 0.79 | SIGMAR1 (0.54) | SIGMAR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL11707719 | 0.79 | KDM4E (0.41) | TMEM97SIGMAR1GSK3BDRD2DRD1 | |
| SCHEMBL20449121 | 0.77 | KDM1A (0.43) | KDM1ATMEM97SIGMAR1GSK3BRPS6KB1 | |
| SCHEMBL20449122 | 0.77 | KDM1A (0.43) | KDM1ATMEM97SIGMAR1GSK3BRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1419545-A | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2003-05-21 | — | — | CN | disclosed |
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |