Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016457 | 0.79 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7020816 | 0.79 | HSP90AA1 (0.63) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7018630 | 0.78 | NPC1 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7011986 | 0.77 | HSP90AA1 (0.51) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL7015297 | 0.77 | NPC1 (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7017485 | 0.75 | EGLN1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL7017772 | 0.74 | NPC1 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL145495 | 0.74 | RAB9A (0.65) | NPC1RAB9AALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL7016726 | 0.72 | SMN1; SMN2 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27575240 | 0.71 | KDM4E (0.53) | ALDH1A1SMN1; SMN2TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155017-B1 | [1,8] NAPHTHYRIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | SHIRE BIOCHEM INC (CA) | 2003-01-15 | — | — | EP | claimed |