Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020816 | 0.81 | HSP90AA1 (0.63) | NPC1RAB9ALMNAL3MBTL1KDM4E | |
| SCHEMBL7015297 | 0.80 | NPC1 (0.49) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL7018848 | 0.79 | LMNA (0.48) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL7011986 | 0.77 | HSP90AA1 (0.51) | NPC1RAB9ALMNAL3MBTL1KDM4E | |
| SCHEMBL7017485 | 0.75 | EGLN1 (0.52) | NPC1RAB9ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL7015247 | 0.74 | NPC1 (0.51) | NPC1RAB9ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL7018630 | 0.73 | NPC1 (0.53) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL7017409 | 0.73 | EGLN1 (0.53) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL21729904 | 0.72 | RAB9A (0.75) | NPC1RAB9ANPSR1KDM4EALDH1A1 | |
| SCHEMBL29484708 | 0.72 | RAB9A (0.75) | NPC1RAB9ANPSR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155017-B1 | [1,8] NAPHTHYRIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | SHIRE BIOCHEM INC (CA) | 2003-01-15 | — | — | EP | claimed |