Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015959 | 0.90 | TP53 (0.44) | MAPTRAB9ATP53TDP1PIK3CD | |
| SCHEMBL7015342 | 0.83 | MAPT (0.46) | MAPTTP53TDP1PIK3CDPIK3CB | |
| Hydrochloric Acid SCHEMBL7013530 | 0.80 | L3MBTL1 (0.39) | MAPTRAB9ATP53TDP1PIK3CD | |
| SCHEMBL7015350 | 0.78 | TP53 (0.44) | MAPTRAB9ATP53TDP1PIK3CD | |
| SCHEMBL7014282 | 0.77 | TP53 (0.41) | MAPTRAB9ATP53TDP1PIK3CD | |
| SCHEMBL7016868 | 0.76 | ENPP2 (0.42) | MAPTRAB9ATP53TDP1PIK3CD | |
| SCHEMBL7016044 | 0.74 | PIK3CD (0.55) | MAPTRAB9ATP53TDP1PIK3CD | |
| SCHEMBL7016621 | 0.72 | TP53 (0.42) | MAPTTP53TDP1PIK3CDPIK3CB | |
| SCHEMBL7016720 | 0.72 | SRD5A2 (0.42) | SRD5A2MAPTTP53TDP1HDAC3 | |
| SCHEMBL7010932 | 0.72 | CYP19A1 (0.42) | MAPTTP53TDP1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |