Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502825 | 0.85 | THRB (0.54) | THRBNPC1RAB9AHPGDASAH1 | |
| SCHEMBL8099116 | 0.80 | HPGD (0.61) | NPC1RAB9AHPGDMAPTPOLB | |
| SCHEMBL12673568 | 0.79 | NPC1 (0.56) | THRBNPC1RAB9AHPGDASAH1 | |
| SCHEMBL4072352 | 0.78 | HPGD (0.49) | THRBNPC1RAB9AHPGDPOLB | |
| SCHEMBL24164390 | 0.78 | NPC1 (0.55) | THRBNPC1RAB9AHPGDTAAR1 | |
| SCHEMBL19559035 | 0.78 | NPC1 (0.55) | THRBNPC1RAB9AHPGDTAAR1 | |
| SCHEMBL4530460 | 0.77 | NPC1 (0.61) | NPC1RAB9ATAAR1MAPTTP53 | |
| SCHEMBL4081360 | 0.77 | POLB (0.54) | THRBNPC1RAB9AHPGDASAH1 | |
| SCHEMBL5907664 | 0.76 | RAB9A (0.54) | NPC1RAB9AHPGDTAAR1POLB | |
| Trifluoroacetic Acid SCHEMBL4555042 | 0.75 | MMP2 (0.52) | THRBNPC1RAB9AHPGDASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |