Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP1 | P07148 | 1/20 | 0.41 |
| ▸ | FABP6 | P51161 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644446 | 0.78 | CYP2D6 (0.38) | FABP1FABP6CYP2D6GABRA5FDPS | |
| SCHEMBL7021148 | 0.75 | CYP2D6 (0.46) | FABP1FABP6CYP2D6GABRA5PCSK9 | |
| SCHEMBL3758388 | 0.69 | CYP2D6 (0.66) | FABP1FABP6CYP2D6PCSK9FDPS | |
| SCHEMBL7022559 | 0.67 | CYP2D6 (0.36) | FABP1FABP6CYP2D6GABRA5PCSK9 | |
| SCHEMBL14198659 | 0.66 | CYP2D6 (0.56) | FABP1FABP6CYP2D6PCSK9FDPS | |
| SCHEMBL1831588 | 0.66 | CYP2D6 (0.56) | FABP1FABP6CYP2D6PCSK9FDPS | |
| SCHEMBL7854740 | 0.64 | RAB9A (0.40) | CYP2D6FDPSCXCR4KDM4EALDH1A1 | |
| SCHEMBL5094987 | 0.64 | GABRA5 (0.43) | FABP1FABP6CYP2D6GABRA5PCSK9 | |
| SCHEMBL17234281 | 0.62 | CYP2D6 (0.58) | FABP1FABP6CYP2D6FDPSCXCR4 | |
| SCHEMBL15208486 | 0.62 | CYP2D6 (0.58) | FABP1FABP6CYP2D6FDPSCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |