Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | ADH5 | P11766 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653307 | 0.81 | KDM4E (0.59) | ALOX15TSHRKDM4EUSP2POLB | |
| SCHEMBL7005980 | 0.81 | CYP3A4 (0.69) | ALOX15TSHRCYP3A4CYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL7653313 | 0.79 | KDM4E (0.57) | ALOX15TSHRKDM4EUSP2POLB | |
| SCHEMBL7010266 | 0.77 | MEN1 (0.75) | ALOX15TSHRCYP3A4CYP2D6MEN1 | |
| SCHEMBL10512975 | 0.73 | LMNA (0.62) | ALOX15TSHRCYP3A4CYP2D6MEN1 | |
| SCHEMBL7011928 | 0.72 | CYP3A4 (0.46) | ALOX15TSHRCYP3A4CYP2D6MEN1 | |
| SCHEMBL451 | 0.71 | CYP3A4 (1.00) | ALOX15TSHRUSP2CYP3A4CYP2D6 | |
| SCHEMBL20000561 | 0.71 | CHRNB2 (0.48) | ALOX15TSHRHPGDCYP3A4ALDH1A1 | |
| SCHEMBL14129948 | 0.70 | CYP2D6 (1.00) | ALOX15TSHRKDM4EUSP2POLB | |
| Ammonia Solution, Strong SCHEMBL3848736 | 0.69 | CYP3A4 (0.95) | ALOX15TSHRUSP2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065209-B1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-05-02 | — | — | EP | disclosed |
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |
| EP-1065209-A1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-03 | — | — | EP | disclosed |