SCHEMBL7653307

SCHEMBL7653307

O=S(=O)(Cl)c1ccc(Oc2ccc(-n3ccnc3)cn2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.59
USP2 O75604 1/20 0.59
POLB P06746 1/20 0.59
HPGD P15428 1/20 0.59
ALOX15 P16050 1/20 0.59
TSHR P16473 1/20 0.59
CYP3A4 P08684 4/20 0.48
CYP2D6 P10635 4/20 0.48
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
CYP1A2 P05177 2/20 0.42
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP19A1 P11511 1/20 0.42
SCN9A Q15858 1/20 0.41
NOS2 P35228 3/20 0.40
CHRNA7 P36544 1/20 0.40
PSEN1 P49768 1/20 0.40
PSEN2 P49810 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7653313 0.88 KDM4E (0.57) KDM4EUSP2POLBHPGDALOX15
SCHEMBL7657342 0.85 CA1 (0.52) KDM4EUSP2POLBHPGDALOX15
SCHEMBL7658197 0.82 ALOX15 (0.53) KDM4EUSP2POLBHPGDALOX15
SCHEMBL7650969 0.82 ALOX15 (0.53) KDM4EUSP2POLBHPGDALOX15
SCHEMBL7015774 0.81 ALOX15 (0.56) KDM4EUSP2POLBHPGDALOX15
SCHEMBL9594739 0.79 NOTUM (0.61) ALOX15TSHRCYP3A4CYP2D6CA1
SCHEMBL7661979 0.77 NAMPT (0.41) KDM4EUSP2POLBHPGDALOX15
SCHEMBL7657456 0.73 CA1 (0.51) KDM4EUSP2POLBHPGDALOX15
SCHEMBL20325535 0.72 LIPE (0.48) KDM4ESCN9A
Hydrochloric Acid SCHEMBL7657350 0.72 CA1 (0.52) KDM4EUSP2POLBHPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6339092-B1 FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS ADIR ET COMPAGNIE (FR) 2002-01-15 US disclosed