Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GALR2 | O43603 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31558260 | 0.82 | ALDH1A1 (0.44) | MAPTALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL19782587 | 0.81 | MGMT (0.50) | ALDH1A1HSP90AA1NPSR1KMT2AL3MBTL1 | |
| SCHEMBL7016542 | 0.77 | IKBKB (0.55) | MAPTALDH1A1SMN1; SMN2HPGDHSP90AA1 | |
| SCHEMBL3216900 | 0.76 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAPOLBHSP90AA1 | |
| SCHEMBL7220292 | 0.74 | ALDH1A1 (0.42) | MAPTALDH1A1SMN1; SMN2LMNAIKBKB | |
| SCHEMBL16401445 | 0.74 | KDM4E (0.66) | MAPTALDH1A1HPGDPOLBNPSR1 | |
| SCHEMBL27344305 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL10181409 | 0.73 | SMN1; SMN2 (0.49) | MAPTALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL8808836 | 0.73 | LMNA (0.46) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL7008118 | 0.73 | KDM4E (0.53) | MAPTALDH1A1LMNAHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610692-B1 | Anticoagulants | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| US-6534510-B2 | Anticoagulants | MERCK & CO., INC. | 2003-03-18 | — | — | US | disclosed |
| EP-1267876-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-6376499-B1 | PIPERAZINE-AMIDE COMPOUND WITH ANTICOAGULANT ACTIVITY | MERCK & CO., INC. | 2002-04-23 | — | — | US | disclosed |
| EP-1124822-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1187616-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6350745-B1 | DIOXO-(PYRIDOOXAZINE) DERIVATIVES; ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |
| US-20020006923-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2002-01-17 | — | — | US | disclosed |
| EP-1082324-A4 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1017383-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6239132-B1 | PREVENTING CORONARY ARTERY DISEASE, INHIBITING LOSS OF BLOOD PLATELETS, INHIBITING FORMATION OF BLOOD PLATELET AGGREGATES, INHIBITING FORMATION OF FIBRIN, INHIBITING THROMBUS FORMATION, AND INHIBITING EMBOLUS FORMATION IN A MAMMAL, | MERCK & CO., INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1082324-A1 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-2000064449-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-11-02 | — | — | WO | disclosed |
| US-6093717-A | A SERINE PROTEASE INHIBITOR PREVENTING CORONARY ARTERY DISEASE AND INHIBITING THROMBUS FORMATION IN BLOOD | MERCK & CO., INC. (US) | 2000-07-25 | — | — | US | disclosed |
| EP-1017383-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2000-07-12 | — | — | EP | disclosed |
| US-6087373-A | A SERINE PROTEASE INHIBITOR FOR PREVENTING OR TREATING UNSTABLE ANGINA, REFRACTORY ANGINA, MYOCARDIAL INFARCTION, TRANSIENT ISCHEMIC ATTACKS, ATRIAL FIBRILLATION, THROMBOTIC STROKE, EMBOLIC STROKE, DEEP VEIN THROMBOSIS | MERCK & CO., INC. (US) | 2000-07-11 | — | — | US | disclosed |
| WO-2000026210-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000026211-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-1999061442-A1 | IMIDAZOPYRIDINE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1999015169-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006923-A1 | Thrombin inhibitors | F2, F11, F12 | MAPT 4865/4885ALDH1A1 2957/4885SMN1; SMN2 4641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.