Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016238 | 0.88 | MAPT (0.43) | TP53TDP1MAPTPOLBHPGD | |
| SCHEMBL7015987 | 0.85 | TP53 (0.47) | TP53TDP1MAPTHPGDLMNA | |
| SCHEMBL7017298 | 0.84 | TP53 (0.46) | TP53TDP1MAPTPOLBHPGD | |
| SCHEMBL7020188 | 0.83 | LMNA (0.46) | TP53TDP1MAPTPOLBHPGD | |
| SCHEMBL7016241 | 0.79 | SMN1; SMN2 (0.43) | TP53TDP1MAPTPOLBLMNA | |
| SCHEMBL7021271 | 0.76 | CYP19A1 (0.41) | TP53TDP1MAPTLMNAMAPK1 | |
| SCHEMBL7017354 | 0.76 | THRB (0.48) | TP53MAPTPOLBHPGDTSHR | |
| SCHEMBL7016056 | 0.75 | THRB (0.47) | TP53MAPTPOLBHPGDTSHR | |
| SCHEMBL7008880 | 0.75 | TP53 (0.37) | TP53TDP1MAPTLMNAMAPK1 | |
| SCHEMBL7015996 | 0.74 | HPGD (0.42) | TP53TDP1MAPTPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |