Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31569732 | 0.76 | TBK1 (0.44) | TBK1DRD2DRD4 | |
| SCHEMBL23964227 | 0.76 | LMNA (0.53) | TBK1VEGFAEGLN1DRD4 | |
| SCHEMBL29111354 | 0.74 | GAA (0.66) | DRD4POLB | |
| SCHEMBL23932558 | 0.74 | RPS6KB1 (0.55) | TBK1 | |
| SCHEMBL23964249 | 0.73 | HRH4 (0.60) | PARP1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL465791 | 0.71 | CHRM2 (0.47) | PARP1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL2862442 | 0.70 | ALDH1A1 (0.60) | CHRM2CHRM4CHRM1CHRM3VEGFA | |
| SCHEMBL9543721 | 0.70 | DRD4 (0.59) | DRD2DRD4 | |
| SCHEMBL659637 | 0.70 | PARP1 (0.46) | PARP1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9933964 | 0.69 | CHRM2 (0.43) | PARP1CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |