Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.30 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804048 | 0.85 | KEAP1 (0.37) | KEAP1NFE2L2TAS2R14ALDH1A1KMT2A | |
| SCHEMBL7012967 | 0.81 | KEAP1 (0.34) | KEAP1NFE2L2TAS2R14ALDH1A1KMT2A | |
| SCHEMBL7013516 | 0.80 | GAA (0.43) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL7011778 | 0.77 | KEAP1 (0.35) | KEAP1CRBNNFE2L2ALDH1A1KMT2A | |
| SCHEMBL7506761 | 0.75 | KEAP1 (0.43) | KEAP1TAS2R14ALDH1A1KMT2AMEN1 | |
| SCHEMBL8377311 | 0.75 | KDM4E (0.44) | KEAP1NFE2L2ALDH1A1KMT2AMEN1 | |
| SCHEMBL27412251 | 0.75 | KEAP1 (0.44) | KEAP1NFE2L2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6648524 | 0.73 | DGAT1 (0.36) | ALDH1A1MAPTKDM4E | |
| SCHEMBL8946849 | 0.72 | KEAP1 (0.35) | KEAP1NFE2L2ALDH1A1MAPTKDM4E | |
| SCHEMBL22954479 | 0.71 | CES2 (0.41) | KEAP1NFE2L2TAS2R14ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |