Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007931 | 0.91 | MAPT (0.47) | MAPTRAB9APOLBTP53KMT2A | |
| SCHEMBL5120468 | 0.75 | ROCK2 (0.50) | ALDH1A1SMN1; SMN2POLBNPY5RLMNA | |
| SCHEMBL7015736 | 0.74 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL7011509 | 0.72 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL5110627 | 0.71 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTPKMLMNA | |
| SCHEMBL5110631 | 0.70 | LMNA (0.55) | MAPTNPY5RLMNA | |
| SCHEMBL5120127 | 0.69 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2MAPTTP53LMNA | |
| SCHEMBL5113480 | 0.66 | ABCC9 (0.51) | ALDH1A1SMN1; SMN2RAB9ANPC1NPY5R | |
| SCHEMBL6339283 | 0.65 | NPY5R (0.57) | NPY5RTP53 | |
| SCHEMBL9053921 | 0.62 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278739-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | AstraZeneca AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001085714-A1 | AMINO SUBSTITUTED DIBENZOTHIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS MEDIATED BY THE NP Y5 RECEPTOR | ASTRAZENECA AB (SE) | 2001-11-15 | — | — | WO | disclosed |