Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016762 | 0.84 | EGLN1 (0.42) | MEN1KMT2APOLBEGLN1ALDH1A1 | |
| SCHEMBL4405550 | 0.80 | LMNA (0.39) | POLBEGLN1SMN1; SMN2LMNA | |
| SCHEMBL1872130 | 0.77 | HPN (0.47) | MEN1KMT2AKCNH2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6321910 | 0.76 | MEN1 (0.41) | MEN1KMT2APOLBKCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1867557 | 0.76 | HPN (0.46) | ALDH1A1KDM4EALOX15PARP1CA12 | |
| SCHEMBL7021172 | 0.75 | TPSAB1 (0.53) | — | |
| SCHEMBL7025350 | 0.75 | TPSAB1 (0.42) | MEN1KMT2AEGLN1ALDH1A1KDM4E | |
| SCHEMBL7019473 | 0.75 | TPSAB1 (0.41) | MEN1KMT2AEGLN1KCNH2CYP2C19 | |
| SCHEMBL7018734 | 0.74 | TPSAB1 (0.46) | PARP1CA12CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL4402047 | 0.74 | TPSAB1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296972-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001090101-A1 | ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-11-29 | — | — | WO | disclosed |