Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089504 | 0.74 | PRKCQ (0.41) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL6644446 | 0.69 | CYP2D6 (0.38) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL7855383 | 0.65 | KDM4E (0.38) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL27560053 | 0.63 | PKM (0.52) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL5089224 | 0.63 | SMN1; SMN2 (0.53) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL11903190 | 0.61 | KMT2A (0.48) | MAPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL27538176 | 0.61 | ADORA1 (0.50) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL17110470 | 0.61 | PIN1 (0.47) | ALDH1A1ACHEBACE1MEN1KMT2A | |
| SCHEMBL11020292 | 0.59 | ALDH1A1 (0.56) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL6804094 | 0.59 | MAPT (0.60) | NPC1RAB9AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |