Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.48 |
| ▸ | CTSV | O60911 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 4/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | DPP4 | P27487 | 4/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018963 | 0.94 | CTSS (0.53) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL7019912 | 0.85 | PREP (0.44) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL4459112 | 0.82 | CTSS (0.50) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL7017106 | 0.80 | CTSS (0.42) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL4451291 | 0.76 | CTSK (0.56) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL4456058 | 0.76 | CTSK (0.38) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL4451610 | 0.76 | CTSS (0.55) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL5254574 | 0.76 | CTSS (0.67) | CTSSCTSVCTSLCTSK | |
| SCHEMBL7017832 | 0.74 | RAB9A (0.45) | CTSSCTSVCTSLCTSKDPP4 | |
| SCHEMBL7014847 | 0.73 | CTSK (0.44) | CTSSCTSVCTSLCTSKDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |