Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.93 |
| ▸ | CHRM4 known ✓ | P08173 | 2/20 | 0.93 |
| ▸ | CHRM5 known ✓ | P08912 | 2/20 | 0.93 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.93 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.93 |
| ▸ | KDM4A | O75164 | 4/20 | 0.55 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.55 |
| ▸ | INSR | P06213 | 3/20 | 0.45 |
| ▸ | CHAT | P28329 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30737946 | 0.99 | CHRM2 (0.91) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL1527120 | 0.96 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL29408332 | 0.96 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL700294 | 0.95 | CHRM2 (0.97) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL3420614 | 0.91 | CHRM2 (0.89) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL3420607 | 0.91 | CHRM2 (0.89) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL13224060 | 0.89 | CHRM2 (0.86) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL1527145 | 0.87 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL10845620 | 0.87 | KDM4A (0.72) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Bromide SCHEMBL10845617 | 0.87 | KDM4A (0.72) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11921117-B2 | Characterization of subvisible particles using a particle analyzer | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-03-05 | — | — | US | disclosed |
| US-20190271706-A1 | CHARACTERIZATION OF SUBVISIBLE PARTICLES USING A PARTICLE ANALYZER | BAXALTA INCORPORATED (US) | 2019-09-05 | — | — | US | disclosed |
| US-10274500-B2 | Characterization of subvisible particles using a particle analyzer | BAXALTA INCORPORATED (US) | 2019-04-30 | — | — | US | disclosed |
| US-8535941-B2 | Lipophilic dye-based FRET assays for clostridial toxin activity | ALLERGAN, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20130177933-A1 | Characterization of Subvisible Particles Using a Particle Analyzer | BAXTER HEALTHCARE SA (CH) | 2013-07-11 | — | — | US | disclosed |
| US-20120231538-A1 | LIPOPHILIC DYE-BASED FRET ASSAYS FOR CLOSTRIDIAL TOXIN ACTIVITY | ALLERGAN, INC. (US) | 2012-09-13 | — | — | US | disclosed |
| US-8232314-B2 | Compounds that protect against sensory hair cell death | UNIVERSITY OF WASHINGTON (US) | 2012-07-31 | — | — | US | disclosed |
| US-8124357-B2 | Cell comprising exogenous clostridial toxin receptor for use as quality control agents in pharmaceutical and food processing | ALLERGAN, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2293064-A1 | Lipophilic dye-based FRET assays for clostridial toxin activity | ALLERGAN, INC. (US) | 2011-03-09 | — | — | EP | disclosed |
| EP-1869459-B1 | LIPOPHILIC DYE-BASED FRET ASSAYS FOR CLOSTRIDIAL TOXIN ACTIVITY | ALLERGAN INC (US) | 2010-06-09 | — | — | EP | disclosed |
| US-20090023751-A1 | COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH | UNIVERSITY OF WASHINGTON (US) | 2009-01-22 | — | — | US | disclosed |
| US-20080160561-A1 | Lipophilic Dye-Based Fret Assays for Clostridal Toxin Activity | ALLERGAN INC. (US) | 2008-07-03 | — | — | US | disclosed |
| US-20060188445-A1 | Assay for compounds that protect against sensory hair cell death and compounds identified by same | FRED HUTCHINSON CANCER RESEARCH CENTER | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060188445-A1 | Assay for compounds that protect against sensory hair cell death and compounds identified by same | AIFM1, CASP3, CASP10 | CHRM2 4776/4885CHRM4 4221/4885CHRM5 4540/4885 |
| US-20090023751-A1 | COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH | AIFM1, CASP3, BAD | CHRM2 4760/4885CHRM4 4301/4885CHRM5 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.