SCHEMBL7017239

SCHEMBL7017239

CN1CCC(c2c[nH]c3ccc(-c4cccnc4)cc23)CC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.59
HTR1D P28221 3/20 0.58
HTR1B P28222 3/20 0.58
CYP1A2 P05177 1/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C9 P11712 1/20 0.58
THPO P40225 1/20 0.58
HTR6 P50406 2/20 0.53
APP P05067 1/20 0.53
DYRK1A Q13627 2/20 0.52
WNT1 P04628 1/20 0.52
HTR1A P08908 1/20 0.51
HTR1F P30939 1/20 0.51
PIM1 P11309 1/20 0.51
PIM3 Q86V86 1/20 0.51
PIM2 Q9P1W9 1/20 0.51
MAPT P10636 1/20 0.50
BLM P54132 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7335724 0.86 HTR6 (0.68) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL27498567 0.81 HTR1D (0.66) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL8097614 0.81 KDM4E (0.58) DRD2HTR1DHTR1BCYP1A2CYP3A4
SCHEMBL27516181 0.80 HTR1D (0.62) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL7013279 0.80 HTR1D (0.64) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL7022272 0.80 HTR1D (0.81) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL9560865 0.80 HTR1D (0.58) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL8786072 0.79 ALDH1A1 (0.53) HTR1DHTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL8176435 0.79 DRD2 (0.61) DRD2HTR1BCYP1A2CYP3A4CYP2D6
SCHEMBL2064650 0.79 HTR1D (0.59) HTR1DHTR1BCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0674620-A1 TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-04 EP claimed
WO-1994014771-A1 TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-07-07 WO claimed
EP-1089993-B1 5-HT1F AGONISTS LILLY CO ELI (US) 2003-10-22 EP disclosed
US-6358972-B1 FOR THERAPY OF MIGRAINE ELI LILLY AND COMPANY 2002-03-19 US disclosed
EP-1089993-A1 5-HT1F AGONISTS ELI LILLY AND COMPANY (US) 2001-04-11 EP disclosed
WO-2000000487-A1 5-HT1F AGONISTS ELI LILLY AND COMPANY (US) 2000-01-06 WO disclosed
EP-0674620-A1 TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1995-10-04 EP disclosed
WO-1994014771-A1 TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS SMITHKLINE BEECHAM PLC (GB) 1994-07-07 WO disclosed