Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.59 |
| ▸ | HTR1B | P28222 | 8/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HTR1F | P30939 | 6/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324777 | 0.83 | KDM4E (0.69) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18324773 | 0.83 | CTSS (0.52) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4774187 | 0.81 | HTR2C (0.62) | HTR1FAPPCTSS | |
| SCHEMBL26912244 | 0.79 | CYP2D6 (0.46) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7017239 | 0.79 | DRD2 (0.59) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30415306 | 0.79 | KDM4E (0.83) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3256692 | 0.79 | KDM4E (0.83) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9101707 | 0.78 | CTSS (0.41) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL27732898 | 0.78 | KDM4E (0.81) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2064426 | 0.78 | SLC6A4 (0.52) | KDM4EATMCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040132734-A1 | Azaindoles having serotonin receptor affinity | NPS ALLELIX CORP. (CA) | 2004-07-08 | — | — | US | claimed |
| EP-1204662-B1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2004-06-02 | — | — | EP | claimed |
| US-20010049441-A1 | Azaindoles having serotonin receptor affnity | ALLELIX BIOPHARMACEUTICALS, INC. | 2001-12-06 | — | — | US | claimed |
| US-20120302596-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | US | disclosed |
| US-8148394-B2 | Azaindoles having serotonin receptor affinity | NPS PHARMACEUTICALS, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20080004307-A1 | Azaindoles Having Serotonin Receptor Affinity | NPS ALLELIX CORP. (CA) | 2008-01-03 | — | — | US | disclosed |
| US-7268127-B2 | Azaindoles having serotonin receptor affinity | NPS ALLELIX CORP (CA) | 2007-09-11 | — | — | US | disclosed |
| US-20050239788-A1 | Substituted with pyrrolopiperazine; schizophrenia, psychosis, depression; inhibition of the 5-HT6 receptor | NPS ALLELIX CORP. (CA) | 2005-10-27 | — | — | US | disclosed |
| US-6916818-B2 | Azaindoles having serotonin receptor affinity | NPS ALLELIX CORP. (CA) | 2005-07-12 | — | — | US | disclosed |
| US-20040132734-A1 | Azaindoles having serotonin receptor affinity | NPS ALLELIX CORP. (CA) | 2004-07-08 | — | — | US | disclosed |
| EP-1204662-B1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP (CA) | 2004-06-02 | — | — | EP | disclosed |
| US-6686374-B1 | Azaindoles having serotonin receptor affinity | NPS ALLELIX CORP. (CA) | 2004-02-03 | — | — | US | disclosed |
| EP-1204662-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS Allelix Corp. (CA) | 2002-05-15 | — | — | EP | disclosed |
| US-20010049441-A1 | Azaindoles having serotonin receptor affnity | ALLELIX BIOPHARMACEUTICALS, INC. | 2001-12-06 | — | — | US | disclosed |
| WO-2001012629-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | NPS ALLELIX CORP. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6191141-B1 | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEN DISORDERS | NPS ALLELIX CORP. (CA) | 2001-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302596-A1 | AZAINDOLES HAVING SEROTONIN RECEPTOR AFFINITY | HTR6, DRD2, HTR1A | HTR1D 8/4885HTR1B 4/4885CYP1A2 348/4885 |
| US-20080004307-A1 | Azaindoles Having Serotonin Receptor Affinity | HTR6, DRD2, HTR1A | HTR1D 8/4885HTR1B 4/4885CYP1A2 348/4885 |
| US-20040132734-A1 | Azaindoles having serotonin receptor affinity | DRD2, HTR3C, HTR2C | HTR1D 14/4885HTR1B 15/4885CYP1A2 405/4885 |
| US-20010049441-A1 | Azaindoles having serotonin receptor affnity | DRD2, DRD3, HTR3C | HTR1D 13/4885HTR1B 25/4885CYP1A2 401/4885 |
| US-20050239788-A1 | Substituted with pyrrolopiperazine; schizophrenia, psychosis, depression; inhibition of the 5-HT6 receptor | CRHR1, HTR6, HTR1A | HTR1D 13/4885HTR1B 20/4885CYP1A2 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.