Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14360622 | 0.82 | MAPT (0.54) | MAPK1GAKTSHRALDH1A1USP2 | |
| SCHEMBL1101894 | 0.77 | MAPK1 (0.60) | MAPK1GAKTSHRALDH1A1USP2 | |
| SCHEMBL7018716 | 0.71 | ERCC5 (0.41) | MAPK1TSHRALDH1A1HTTGAA | |
| SCHEMBL3754226 | 0.70 | GAK (0.67) | MAPK1GAKALDH1A1USP2LMNA | |
| Potassium Ion SCHEMBL3689408 | 0.68 | GAK (0.63) | MAPK1GAKTSHRALDH1A1USP2 | |
| SCHEMBL7018863 | 0.67 | KDM4E (0.33) | ALDH1A1LMNAHTTNPC1RAB9A | |
| SCHEMBL14478932 | 0.67 | ALDH1A1 (0.63) | MAPK1TSHRALDH1A1USP2LMNA | |
| SCHEMBL12718463 | 0.64 | MAPK1 (0.43) | MAPK1GAKTSHRGAAMAPT | |
| SCHEMBL11299230 | 0.64 | GAK (0.57) | MAPK1GAKTSHRALDH1A1USP2 | |
| SCHEMBL799433 | 0.63 | ADORA2B (0.45) | MAPK1TSHRALDH1A1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836602-B1 | FUNGICIDAL PYRIMIDINONES | DU PONT (US) | 2002-01-30 | — | — | EP | claimed |
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-6348504-B1 | COMPOUNDS WITH AMIDINE OR GUANIDINE GROUPS AND CARBOXY OR ESTER GROUPS THROMBOLYTICS AND/OR FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS. | DUPONT PHARMACEUTICALS COMPANY | 2002-02-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |