Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70473 | 0.87 | RXFP1 (0.59) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL84505 | 0.78 | RXFP1 (0.62) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL69730 | 0.77 | HTR1A (0.40) | ALDH1A1 | |
| SCHEMBL71309 | 0.72 | RXFP1 (0.79) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL70462 | 0.70 | HTR1A (0.41) | ALDH1A1SMN1; SMN2HTTKMT2ARAB9A | |
| SCHEMBL2369050 | 0.68 | ALDH1A1 (0.74) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL8189689 | 0.67 | ALDH1A1 (0.70) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15435583 | 0.66 | HTR1A (0.37) | ALDH1A1SMN1; SMN2HTTKMT2AMEN1 | |
| SCHEMBL8203415 | 0.65 | ALDH1A1 (0.66) | RXFP1ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL71355 | 0.63 | GAA (0.42) | ALDH1A1SMN1; SMN2KMT2ARAB9AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209791-B1 | Heterocyclic derivatives | MERCK SHARP & DOHME (NL) | 2014-01-22 | — | — | EP | disclosed |
| EP-2209791-B1 | Heterocyclic derivatives | MERCK SHARP & DOHME (NL) | 2014-01-22 | — | — | EP | disclosed |
| US-8129397-B2 | Substituted thieno[2,3-d]pyrimidines as AMPA modulators | MSD OSS B.V. (US) | 2012-03-06 | — | — | US | disclosed |
| US-8129397-B2 | Substituted thieno[2,3-d]pyrimidines as AMPA modulators | MSD OSS B.V. (US) | 2012-03-06 | — | — | US | disclosed |
| WO-2009062930-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2009-05-22 | — | — | WO | disclosed |
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2009-05-21 | — | — | US | disclosed |
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131455-A1 | HETEROCYCLIC DERIVATIVES | GRIN2C, GRIK5, GRIN1 | RXFP1 1588/4885ALDH1A1 398/4885LMNA 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.