Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 6/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL702635 | 0.98 | TSHR (0.40) | NOS3FGFR1FGFR2TSHRNOS2 | |
| SCHEMBL702681 | 0.78 | NOS3 (0.35) | NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL703084 | 0.77 | NOS3 (0.35) | NOS3NOS2 | |
| SCHEMBL2490801 | 0.69 | DDB1 (0.47) | FGFR1FGFR2CYP19A1AKT1 | |
| SCHEMBL11748567 | 0.69 | FGFR1 (0.43) | FGFR1FGFR2CYP19A1 | |
| SCHEMBL8105441 | 0.68 | NOS2 (0.39) | NOS3TSHRNOS2 | |
| SCHEMBL1681655 | 0.68 | HTR2A (0.43) | FGFR1TSHRJAK2 | |
| SCHEMBL10641436 | 0.66 | FGFR1 (0.37) | FGFR1FGFR2CYP19A1 | |
| Hydrochloric Acid SCHEMBL10641022 | 0.65 | FGFR1 (0.36) | FGFR1FGFR2CYP19A1 | |
| SCHEMBL19566504 | 0.63 | HSD17B10 (0.50) | FGFR1TSHRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124621-B2 | Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them | SANOFI-AVENTIS (FR) | 2012-02-28 | — | — | US | claimed |
| EP-1999113-B1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI AVENTIS (FR) | 2009-08-19 | — | — | EP | claimed |
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | claimed |
| EP-1999113-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | Sanofi-Aventis (FR) | 2008-12-10 | — | — | EP | claimed |
| WO-2007107245-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2007-09-27 | — | — | WO | claimed |
| US-8124621-B2 | Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them | SANOFI-AVENTIS (FR) | 2012-02-28 | — | — | US | disclosed |
| US-8124621-B2 | Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them | SANOFI-AVENTIS (FR) | 2012-02-28 | — | — | US | disclosed |
| US-8124621-B2 | Substituted 1-amino-4-phenyl-dihydroisoquinolines, methods for the production thereof, use thereof as a medicament, and medicaments containing them | SANOFI-AVENTIS (FR) | 2012-02-28 | — | — | US | disclosed |
| EP-1999113-B1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI AVENTIS (FR) | 2009-08-19 | — | — | EP | disclosed |
| EP-1999113-B1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI AVENTIS (FR) | 2009-08-19 | — | — | EP | disclosed |
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | disclosed |
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | disclosed |
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | US | disclosed |
| EP-1999113-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | Sanofi-Aventis (FR) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107245-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007107245-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | SANOFI-AVENTIS (FR) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118327-A1 | SUBSTITUTED 1-AMINO-4-PHENYL-DIHYDROISOQUINOLINES, METHODS FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT, AND MEDICAMENTS CONTAINING THEM | NDUFAB1, ABCB11, SLC10A1 | NOS3 2702/4885FGFR1 269/4885FGFR2 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.