Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 16/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011415 | 0.84 | LTA4H (0.41) | PLA2G1BBAZ2BBAZ2A | |
| SCHEMBL7006699 | 0.82 | PLA2G1B (0.39) | PLA2G1BPLA2G2ABAZ2BBAZ2A | |
| SCHEMBL7011897 | 0.78 | TAS1R3 (0.45) | PLA2G1BPLA2G2ABAZ2BBAZ2A | |
| SCHEMBL7013787 | 0.72 | CYP1A2 (0.47) | BAZ2BBAZ2A | |
| SCHEMBL8079805 | 0.71 | PLA2G2A (0.48) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 | |
| SCHEMBL4961133 | 0.70 | PTPN1 (0.50) | — | |
| SCHEMBL7013421 | 0.69 | PLA2G1B (0.59) | PLA2G1BPLA2G2ABAZ2BBAZ2APLA2G2E | |
| SCHEMBL7012314 | 0.68 | ADORA2A (0.37) | PLA2G1BPLA2G2A | |
| SCHEMBL7010500 | 0.68 | PLA2G1B (0.55) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 | |
| SCHEMBL7013828 | 0.68 | PLA2G1B (0.67) | PLA2G1BPLA2G2APLA2G2EPLA2G5PLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |