SCHEMBL70184

SCHEMBL70184

COC(=O)c1cc(-c2ccc(C)c(C(=O)OC)c2)ccc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MCL1 Q07820 1/20 0.46
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
PDK2 Q15119 1/20 0.46
PDK4 Q16654 1/20 0.46
SLC6A3 Q01959 4/20 0.45
SLC6A4 P31645 3/20 0.45
SLC6A2 P23975 1/20 0.45
NR4A2 P43354 2/20 0.44
LMNA P02545 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9157976 0.93 MCL1 (0.53) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7666837 0.93 ALDH1A1 (0.50) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL9149067 0.93 KDM4E (0.46) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7671667 0.91 NR4A2 (0.56) KDM4EMCL1SLC6A3SLC6A4SLC6A2
SCHEMBL7667046 0.89 SLC6A3 (0.55) KDM4ESLC6A3SLC6A4SLC6A2NR4A2
SCHEMBL9149082 0.88 MCL1 (0.53) KDM4EMCL1CA12CA1CA2
SCHEMBL31049810 0.87 NR4A2 (0.46) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL27348225 0.85 LOXL2 (0.54) KDM4ECA12CA1CA2CA9
SCHEMBL1709635 0.85 MCL1 (0.53) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL2181370 0.84 MAPT (0.52) KDM4ECA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2479203-A1 AROMATIC POLYESTER Muroran Institute of Technology (JP) 2012-07-25 EP disclosed
US-20120172570-A1 AROMATIC POLYESTER NITTA CORPORATION 2012-07-05 US disclosed
US-8129493-B2 Aromatic polyester MURORAN INSTITUTE OF TECHNOLOGY (JP) 2012-03-06 US disclosed
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME MURORAN INSTITUTE OF TECHNOLOGY (JP) 2011-09-15 US disclosed
US-20110092662-A1 AROMATIC POLYESTER NITTA CORPORATION (JP) 2011-04-21 US disclosed
EP-0439616-B1 METHOD OF PRODUCING 3,4,3',4'-SUBSTITUTED BIPHENYL COMPOUNDS UBE INDUSTRIES (JP) 1995-01-04 EP disclosed
US-5243067-A Oxidative coupling UBE INDUSTRIES, LTD. (JP) 1993-09-07 US disclosed
EP-0439616-A1 METHOD OF PRODUCING 3,4,3',4'-SUBSTITUTED BIPHENYL COMPOUNDS UBE INDUSTRIES, LTD. (JP) 1991-08-07 EP disclosed
EP-0396564-A1 PROCESS FOR THE PREPARATION OF STILBENEDICARBOXYLATE DERIVATIVES EASTMAN KODAK COMPANY (US) 1990-11-14 EP disclosed
US-4847407-A INTERMEDIATES FOR POLYESTERS EASTMAN KODAK COMPANY (US) 1989-07-11 US disclosed
WO-1989003380-A1 PROCESS FOR THE PREPARATION OF STILBENEDICARBOXYLATE DERIVATIVES EASTMAN KODAK COMPANY (US) 1989-04-20 WO disclosed
US-4789755-A DEHYDRODIMERIZATION OF METHYL OR PHENYL TOLUATES EASTMAN KODAK COMPANY (US) 1988-12-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224343-A1 MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME F12, PHAX, WDR82 KDM4E 717/4885CYP1A2 2262/4885CYP2D6 3747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.