SCHEMBL7018449

SCHEMBL7018449

CNC(C=CC#CC(C)(C)C)Cc1cccc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.53
CYP2D6 P10635 2/20 0.53
LMNA P02545 1/20 0.53
ADRA2A P08913 1/20 0.53
SLC6A2 P23975 1/20 0.53
SQLE Q14534 1/20 0.53
CTSS P25774 1/20 0.36
CTSK P43235 1/20 0.36
CTNNB1 P35222 1/20 0.35
OPRD1 P41143 1/20 0.35
OPRK1 P41145 1/20 0.35
CYP1A2 P05177 2/20 0.35
CYP2C19 P33261 2/20 0.35
MTNR1A P48039 1/20 0.34
ADRB2 P07550 4/20 0.34
MMP9 P14780 1/20 0.34
CYP2C9 P11712 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11399752 0.81 SIGMAR1 (0.39) SIGMAR1CYP2D6CTNNB1CYP1A2CYP2C19
SCHEMBL11397476 0.79 SIGMAR1 (0.37) SIGMAR1CYP2D6LMNAADRA2ASLC6A2
SCHEMBL6273693 0.79 SIGMAR1 (0.52) SIGMAR1CYP2D6LMNAADRA2ASLC6A2
SCHEMBL11407941 0.76 MME (0.36) SIGMAR1CTNNB1ADRB2MMP9
SCHEMBL30960251 0.75 LMNA (0.60) SIGMAR1CYP2D6LMNAADRA2ASLC6A2
SCHEMBL3256688 0.75 LMNA (0.60) SIGMAR1CYP2D6LMNAADRA2ASLC6A2
SCHEMBL30960258 0.75 LMNA (0.60) SIGMAR1CYP2D6LMNAADRA2ASLC6A2
SCHEMBL3256682 0.75 LMNA (0.60) SIGMAR1CYP2D6LMNAADRA2ASLC6A2
SCHEMBL9631575 0.75 CTNNB1 (0.45) SIGMAR1CYP2D6CTNNB1CYP1A2CYP2C19
SCHEMBL9727662 0.75 CTNNB1 (0.45) SIGMAR1CYP2D6CTNNB1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1222160-B1 PROCESS FOR PREPARING A SUBSTITUTED ALLYLAMINE DERIVATIVE AND THE SALTS THEREOF RICHTER GEDEON VEGYESZET (HU) 2003-07-23 EP disclosed
EP-1222160-A1 PROCESS FOR PREPARING A SUBSTITUTED ALLYLAMINE DERIVATIVE AND THE SALTS THEREOF RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) 2002-07-17 EP disclosed
WO-2001028976-A1 PROCESS FOR PREPARING A SUBSTITUTED ALLYLAMINE DERIVATIVE AND THE SALTS THEREOF Richter Gedeon Vegyészeti Gyár Rt. (HU) 2001-04-26 WO disclosed