Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179119 | 0.91 | ALDH1A1 (0.45) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8170398 | 0.90 | HSD17B10 (0.47) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7013836 | 0.89 | PDE5A (0.52) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8181999 | 0.88 | PDE5A (0.52) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5130013 | 0.87 | MAPT (0.53) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8178910 | 0.87 | USP1 (0.51) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8185519 | 0.87 | PDE5A (0.50) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8179417 | 0.86 | PDE5A (0.49) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8171150 | 0.86 | LMNA (0.43) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8178013 | 0.85 | FYN (0.48) | PDE5ACYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | claimed |
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | claimed |
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |