Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.70 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NQO2 | P16083 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18229463 | 0.87 | KMT2A (0.73) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL798104 | 0.85 | MTNR1A (0.72) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL7501961 | 0.85 | KMT2A (0.81) | MTNR1AMTNR1BKDM4EHTR2AKMT2A | |
| SCHEMBL11190375 | 0.84 | KDM4E (0.71) | MTNR1AMTNR1BKDM4EKMT2AMEN1 | |
| SCHEMBL7023379 | 0.84 | HTR1A (0.58) | MTNR1AMTNR1BKDM4EHTR2ASIGMAR1 | |
| SCHEMBL7023934 | 0.83 | LMNA (0.64) | KDM4EKMT2AMAPTALDH1A1CYP1A2 | |
| SCHEMBL8252641 | 0.83 | KDM4E (0.73) | MTNR1AMTNR1BKDM4EHTR2AKMT2A | |
| SCHEMBL5239218 | 0.83 | KDM4E (0.73) | MTNR1AMTNR1BKDM4EHTR2AKMT2A | |
| SCHEMBL1853622 | 0.82 | LMNA (0.71) | KDM4ESIGMAR1KMT2AMEN1MAPT | |
| SCHEMBL6862429 | 0.82 | KDM4E (0.71) | MTNR1AMTNR1BKDM4EHTR2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057826-B1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-04-16 | — | — | EP | disclosed |
| US-6310074-B1 | TREATING MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-10-30 | — | — | US | disclosed |
| EP-1057826-A1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-12-06 | — | — | EP | disclosed |