Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.64 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853622 | 0.86 | LMNA (0.71) | LMNAALDH1A1HPGDHTTKMT2A | |
| SCHEMBL807557 | 0.84 | TRPV1 (0.70) | ALDH1A1HPGDNPSR1TRPV1KMT2A | |
| SCHEMBL6077115 | 0.83 | TRPV1 (0.75) | LMNAALDH1A1HPGDNPSR1TRPV1 | |
| SCHEMBL7018937 | 0.83 | MTNR1A (0.70) | ALDH1A1HPGDPMP22KMT2AMAPT | |
| SCHEMBL20182375 | 0.81 | NPSR1 (0.70) | LMNAALDH1A1HPGDNPSR1GLA | |
| SCHEMBL20182374 | 0.80 | NPSR1 (0.68) | LMNAALDH1A1HPGDNPSR1GLA | |
| SCHEMBL24205751 | 0.80 | ALDH1A1 (0.64) | LMNAALDH1A1HPGDNPSR1GLA | |
| SCHEMBL17209331 | 0.79 | KMT2A (0.70) | LMNAALDH1A1HPGDNPSR1GLA | |
| SCHEMBL138121 | 0.79 | NPSR1 (1.00) | LMNAALDH1A1HPGDNPSR1GLA | |
| SCHEMBL29350604 | 0.79 | NPSR1 (1.00) | LMNAALDH1A1HPGDNPSR1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057826-B1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-04-16 | — | — | EP | disclosed |
| EP-1057826-A1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-12-06 | — | — | EP | disclosed |