Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | CTSV | O60911 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 8/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019711 | 0.89 | LMNA (0.52) | CTSKCTSSCTSVCTSLNPC1 | |
| SCHEMBL7024341 | 0.87 | NAMPT (0.48) | CTSKCTSSCTSVCTSLDRD2 | |
| SCHEMBL7017128 | 0.85 | CTSK (0.44) | CTSKCTSSCTSVCTSLNPC1 | |
| SCHEMBL7021109 | 0.83 | CTSK (0.41) | CTSKCTSSCTSVCTSLNPC1 | |
| SCHEMBL4452660 | 0.83 | CTSK (0.49) | CTSKTSHRCTSSCTSVCTSL | |
| SCHEMBL7016446 | 0.81 | HDAC1 (0.48) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL7014847 | 0.78 | CTSK (0.44) | CTSKTSHRCTSSCTSVCTSL | |
| SCHEMBL7023221 | 0.76 | HDAC3 (0.41) | CTSKCTSSCTSVCTSLDRD2 | |
| SCHEMBL4446769 | 0.74 | CTSS (0.44) | CTSKCTSSCTSVCTSLNPC1 | |
| SCHEMBL4459563 | 0.74 | CTSK (0.65) | CTSKTSHRCTSSCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |